ERα系列抗体的应用研究（雌激素受体研究值得关注）

引言：  雌激素受体alpha (ERα)分布于子宫、睾丸、脑下垂体、肾、附睾、肾上腺、乳腺等组织，其作为核转录因子参与人体多种复杂生理过程的调节。ERα受体表达和调节的研究对多种疾病的预防和治疗有积极意义，例如癌症、代谢性疾病、心血管疾病、神经退行性疾病、炎症和骨质疏松症等[1]。蛋白表达在ERα受体表达调节研究中占有重要地位，而ERα抗体则是ERα受体表达的重要研究工具。 

       雌激素受体alpha (ERα)分布于子宫、睾丸、脑下垂体、肾、附睾、肾上腺、乳腺、骨等组织，其作为核转录因子参与人体多种复杂生理过程的调节。ERα受体表达和调节的研究对多种疾病的预防和治疗有积极意义，例如癌症、代谢性疾病、心血管疾病、神经退行性疾病、炎症和骨质疏松症等[1]。蛋白表达在ERα受体表达调节研究中占有重要地位，而ERα抗体则是ERα受体表达的重要研究工具。 

      ERα受体包括多个功能结构域，不同的转录剪接产生不同的转录异构体[2],主要包括ERα36和ERα46。由于与疾病的密切相关性，ERα36、ERα46和野生型ERα (ERα66)一起成为ER家族研究热点，相应的抗体也成为对应的研究工具。美国CHI Scientific提供的 ERα系列（ER-α36, ER-α46 & 66, ER-α36）抗体灵敏度高，特异性强，自面试以来，引用该系列产品的文献达上百篇。尤其是Anti-hER-α36抗体，为美国CHI Scientific生产销售的产品，为广大中外科研学者研究ERα36相关疾病提供强有力支撑。

论文截图：
 

Anti-hER-α36：

The antibody was raised against a synthetic peptide antigen corresponding to the unique C-terminal 20 amino acids of hER-α36. The specificity of the antibody was tested in hER-α36 expression vector transfected HEK293 cells that do not express endogenous hER-α. Immunofluorescence was used to demonstrate immunoreactive signals only in transfectants with the hER-α36-expressing vectors but not in transfectants harboring an empty expression vector. This rabbit polyclonal anti-hER-α36 antibody is supplied in affinity-purified form.

（引用SCI论文截图）

Anti-hER-α46 & ER-α66:

The antibody was raised against a synthetic peptide antigen corresponding to the unique C-terminal 18 amino acids of hER-α66. The specificity of the antibody was tested in hER-α46 and hER-α66 expression cells, MCF-7 Cells and breast carcinoma tissues. This rabbit polyclonal anti-hER-α46 & hER-α66 antibody is supplied in affinity-purified form.

（引用SCI论文截图）

Anti-hER-α66：

 The antibody was raised against a synthetic peptide antigen corresponding to the unique C-terminal 18 amino acids of hER-α66. The specificity of the antibody was tested in hER-α66 expression cells, MCF-7 Cells and breast carcinoma tissues. This rabbit polyclonal anti-hER-α66 antibody is supplied in affinity-purified form.

（引用SCI论文截图）

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更多引用:

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